Oxidized yeast glucan alleviates lead-induced toxicity in mice by improving intestinal health to inhibit Pb absorption and reducing kidney oxidative stress

Shuai Chen; Xinyi Zhu; Yujie Guo; Ningzhe Kang; Qilin Huang

doi:10.1016/j.ijbiomac.2024.139205

Oxidized yeast glucan alleviates lead-induced toxicity in mice by improving intestinal health to inhibit Pb absorption and reducing kidney oxidative stress

Int J Biol Macromol. 2024 Dec 27:292:139205. doi: 10.1016/j.ijbiomac.2024.139205. Online ahead of print.

Authors

Shuai Chen¹, Xinyi Zhu¹, Yujie Guo¹, Ningzhe Kang¹, Qilin Huang²

Affiliations

¹ College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; MOE Key Laboratory of Environment Correlative Dietology, Huazhong Agricultural University, Wuhan 430070, China.
² College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; MOE Key Laboratory of Environment Correlative Dietology, Huazhong Agricultural University, Wuhan 430070, China. Electronic address: hql@mail.hzau.edu.cn.

PMID: 39733907
DOI: 10.1016/j.ijbiomac.2024.139205

Abstract

This study investigated the protective effects and Pb-excretion mechanisms of yeast glucans (YG) with varying oxidation degrees in Pb-exposed mice. Results demonstrated that all three glucans effectively reduced blood lead levels, alleviated inflammation, and mitigated liver damage in Pb-exposed mice, with highly oxidized yeast glucan (OYG2) exhibiting the greatest efficacy. Furthermore, the glucans attenuated Pb-induced oxidative stress and pathological changes in the kidney by elevating glutathione and superoxide dismutase levels, thereby restoring renal excretory function (blood urea nitrogen and creatinine). This restoration contributed to maintaining electrolyte homeostasis (Na⁺, Cl^-, K⁺) and significantly enhanced lead excretion efficiency via urine. Additionally, the glucans modulated intestinal microbiota balance, promoted short-chain fatty acid production, and repaired Pb-induced intestinal barrier damage by upregulating tight junction proteins (ZO-1, Occludin, Claudin-1). In conclusion, yeast glucans, particularly OYG2, effectively inhibited Pb absorption and facilitated its excretion through feces, highlighting their potential as a therapeutic strategy for lead toxicity.

Keywords: Lead excretion; Lead exposure; Microbial composition; Oxidative stress; Yeast glucan.