Advances in research on the impact and mechanisms of pathogenic microorganism infections on pyroptosis

Pan Shang; Mailin Gan; Ziang Wei; Shijie Hu; Lei Song; Jinkang Feng; Lei Chen; Lili Niu; Yan Wang; Shunhua Zhang; Linyuan Shen; Li Zhu; Ye Zhao

doi:10.3389/fmicb.2024.1503130

Advances in research on the impact and mechanisms of pathogenic microorganism infections on pyroptosis

Front Microbiol. 2024 Dec 13:15:1503130. doi: 10.3389/fmicb.2024.1503130. eCollection 2024.

Authors

Pan Shang^#^{1

2}, Mailin Gan^#^{1

2}, Ziang Wei^{1

2}, Shijie Hu^{1

2}, Lei Song^{1

2}, Jinkang Feng^{1

2}, Lei Chen^{1

2}, Lili Niu^{1

2}, Yan Wang^{1

2

3}, Shunhua Zhang^{1

2}, Linyuan Shen^{1

2

3}, Li Zhu^{1

2

3}, Ye Zhao^{1

2

3}

Affiliations

¹ Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
² State Key Laboratory of Swine and Poultry Breeding Industry, Sichuan Agricultural University, Chengdu, China.
³ Key Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, College of Animal and Technology, Sichuan Agricultural University, Chengdu, China.

^# Contributed equally.

Abstract

Pyroptosis, also known as inflammatory necrosis, is a form of programmed cell death characterized by the activation of gasdermin proteins, leading to the formation of pores in the cell membrane, continuous cell swelling, and eventual membrane rupture. This process results in the release of intracellular contents, including pro-inflammatory cytokines like IL-1β and IL-18, which subsequently trigger a robust inflammatory response. This process is a crucial component of the body's innate immune response and plays a significant role in combating infections. There are four main pathways through which pathogenic microorganisms induce pyroptosis: the canonical inflammasome pathway, the non-canonical inflammasome pathway, the apoptosis-associated caspase-mediated pathway, and the granzyme-mediated pathway. This article provides a brief overview of the effects and mechanisms of pathogen infections on pyroptosis.

Keywords: caspase; granzyme; inflammasome; pathogenic microorganisms; pyroptosis.

Publication types

Review

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by China Agriculture Research System (CARS-35); Sichuan Science and Technology Program (2021YFYZ0007, 2021ZDZX0008, 2021YFYZ0030); The Program for Pig Industry Technology System Innovation Team of Sichuan Province (SCCXTD-2024-8); National Center of Technology Innovation for Pigs (NCTIP-XD/C13).