Relationship between triglyceride glucose-body mass index and coronary artery calcium score in maintenance hemodialysis patients

Zexi Jiang; Jinhua Zhu; Hong Ding; Lihong Yan; Ruoxin Chen; Bin Wang; ZuoLin Li; Hong Liu

doi:10.3389/fmed.2024.1478090

Relationship between triglyceride glucose-body mass index and coronary artery calcium score in maintenance hemodialysis patients

Front Med (Lausanne). 2024 Dec 13:11:1478090. doi: 10.3389/fmed.2024.1478090. eCollection 2024.

Authors

Zexi Jiang^#¹, Jinhua Zhu^#², Hong Ding², Lihong Yan¹, Ruoxin Chen¹, Bin Wang¹, ZuoLin Li¹, Hong Liu¹

Affiliations

¹ Institute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
² Institute of Nephrology, People's Hospital of Yangzhong City, Zhenjiang, Jiangsu, China.

^# Contributed equally.

Abstract

Background: This study investigated the association between coronary artery calcification (CAC) and triglyceride glucose-body mass index (TyG-BMI) in patients receiving maintenance hemodialysis (MHD).

Methods: We used computed tomography (CT) to assess coronary artery calcification score (CACS) using the Agatston method. The TyG index was multiplied by BMI to derive the TyG-BMI index. Ordinal logistic regression models were used to analyze the relationship between TyG-BMI and CAC. The dose-response relationship was evaluated using restricted cubic spline regression. Weighted Quantile Sum regression was used to explore the weight of the TyG-BMI index components.

Results: Based on the TyG-BMI, 219 patients with MHD were stratified into three groups. The TyG-BMI index was shown to be an independent risk factor for CACS by multivariate ordinal logistic regression analysis (odds ratio, 1.011; [95% confidence interval, 1.002-1.021]; P = 0.021). The relationship between TyG-BMI and lg (CACS + 10) was linear (P-overall = 0.023, P-non-linear = 0.412). Body mass index (BMI) had the highest weight (0.566) when weights were assigned to the three components of TyG-BMI. In the non-diabetes and diabetes subgroups, TyG-BMI and lg (CACS + 10) did not exhibit a significant non-linear relationship.

Conclusion: TyG-BMI and CAC were independently positively correlated in patients undergoing MHD. These findings suggest that assessing TyG-BMI as a valuable tool for identifying the risk of CAC in patients with MHD.

Keywords: cardiovascular disease; coronary artery calcification; insulin resistance; maintenance hemodialysis; triglyceride glucose-body mass index.

Grants and funding

The authors declare that financial support was received for the research, authorship, and/or publication of this article. This study was supported by the Key Scientific Research Project of Integrated Traditional Chinese and Western Medicine in Zhongda Hospital affiliated to Southeast University (2023zxyxt01) and the Zhenjiang Key Research and Development Plan (Social Development) Project (SH2023007).