Generation of a human induced pluripotent stem cell line NTUHi006-A from a polycystic ovarian syndrome patient

Chia-Eng Wu; Hsiang-Po Huang; Hong-Nerng Ho; Mei-Jou Chen

doi:10.1016/j.scr.2024.103647

Generation of a human induced pluripotent stem cell line NTUHi006-A from a polycystic ovarian syndrome patient

Stem Cell Res. 2024 Dec 30:82:103647. doi: 10.1016/j.scr.2024.103647. Online ahead of print.

Authors

Chia-Eng Wu¹, Hsiang-Po Huang², Hong-Nerng Ho³, Mei-Jou Chen⁴

Affiliations

¹ Department of Obstetrics and Gynecology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
² Graduate Institute of Medical Genomics and Proteomics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
³ Department of Obstetrics and Gynecology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Research Center for Cell Therapy and Regeneration Medicine, Taipei Medical University, Taipei, Taiwan.
⁴ Department of Obstetrics and Gynecology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Livia Shangyu Wan Chair Professor of Obstetrics and Gynecology, National Taiwan University, Taipei, Taiwan Research Center for Cell Therapy and Regeneration Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: mjchen04@ntu.edu.tw.

PMID: 39742630
DOI: 10.1016/j.scr.2024.103647

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disorder related to multifactors and genetic polymorphisms. Here, we derived an induced pluripotent stem cell (hiPSC) line NTUHi006-A from a phenotype A (full-blown) PCOS patients with clinical hyperandrogenism, chronic anovulation, and polycystic ovarian morphology on ultrasonography. NTUHi006-A showed stemness, pluripotency and stem cell-like morphology.