Hepatocellular carcinoma (HCC) is a kind of malignant tumor with an extremely high morbidity and mortality incidence rate. Although some new progress has been made in recent treatment, the overall prognosis is still poor. Therefore, the prevention and treatment of HCC have important clinical significance. Statin drugs are mainly used for the treatment of hypercholesterolemia and the prevention of cardiovascular and cerebrovascular diseases. In recent years, an increasing number of research results have shown that statins have advantages in preventing the occurrence and improving the prognosis of HCC. This paper reviews the new progress performed in the mechanism of statin drug and the current clinical prevention and treatment for HCC.
肝细胞癌（HCC）是一种发病率和病死率极高的恶性肿瘤，尽管目前在治疗上取得了一些新进展，但整体预后仍不佳。因此，HCC的防治具有重要的临床意义。他汀类药物主要用于高胆固醇血症的治疗及心脑血管疾病的预防。近年越来越多的研究结果显示他汀类药物在预防HCC发生及改善HCC预后方面显示出优势。现就他汀类药物抗HCC的机制及目前其临床防治HCC的新进展进行综述。.