Utility of FDG PET/CT in Sjögren's Syndrome and associated lymphomas; Lymphomagenesis

Dikhra Khan; Prateek Kaushik; Sambit Sagar; Jasim Jaleel

doi:10.22038/aojnmb.2024.76893.1541

Utility of FDG PET/CT in Sjögren's Syndrome and associated lymphomas; Lymphomagenesis

Asia Ocean J Nucl Med Biol. 2025;13(1):102-106. doi: 10.22038/aojnmb.2024.76893.1541.

Authors

Dikhra Khan¹, Prateek Kaushik¹, Sambit Sagar¹, Jasim Jaleel²

Affiliations

¹ India Department Of Nuclear Medicine All India Institute of Medical Sciences, Delhi, India.
² Department of Nuclear Medicine, Institute of Liver and Biliary Sciences, New Delhi, Delhi, India.

Abstract

Primary Sjögren syndrome (SS) is an autoimmune disease affecting exocrine glands, with predisposition to development of lymphoma (lymphomagenesis). We report a case of Sjogren's syndrome and discuss the role of FDG PET/CT in the primary diagnosis of lymphoma transformation in SS. Furthermore, we reviewed the literature regarding the utility of FDG PET/CT to assess systemic disease activity and also its role in the SS associated lymphoma with light into the new PET tracers that can be explored for these indications in the future. Published data suggest promising role of FDG PET/CT in SS associated lymphomas, and demands larger studies for its establishment.

Keywords: FDG; Lymphoma; Lymphomagenesis; PET/CT; Primary Sjögren syndrome.

Publication types

Review