Abstract
A novel, highly diastereoselective, and metal-free synthesis of multisubstituted piperidines via an SN1 approach is reported in this study. The method allows for the preparation of highly functionalized compounds with exceptional diastereomeric selectivities and consistently reproducible yields. These compounds are of significant interest due to their remarkable biological activities toward influenza endonuclease.
MeSH terms
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Antiviral Agents / chemical synthesis
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology
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Endonucleases* / antagonists & inhibitors
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Endonucleases* / metabolism
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Metals / chemistry
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Molecular Structure
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Orthomyxoviridae / drug effects
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Orthomyxoviridae / enzymology
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Piperidines* / chemical synthesis
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Piperidines* / chemistry
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Stereoisomerism
Substances
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Piperidines
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Endonucleases
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Enzyme Inhibitors
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Antiviral Agents
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piperidine
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Metals