Circular RNAs in the pathogenesis of SARS-CoV-2: potential diagnostic biomarkers and therapeutic targets

Funct Integr Genomics. 2025 Jan 2;25(1):4. doi: 10.1007/s10142-024-01509-6.

Abstract

Since December 2019, the global dissemination of a novel coronavirus has precipitated a notable public health crisis, prompting considerable interest and scrutiny from governmental and scholarly entities. Substantial research efforts have been dedicated to exploring diverse facets of this novel coronavirus, encompassing its pathogenesis, transmission dynamics, and therapeutic interventions. Recent findings suggest that circular RNAs (circRNAs) exert a pivotal influence on modulating viral infectivity and immune defense mechanisms. The detection of differentially expressed circRNAs in individuals afflicted with SARS-CoV-2 signifies a noteworthy advancement in understanding the molecular mechanisms underpinning viral pathogenesis.

Keywords: Circular RNAs; Non-coding RNA; RNA treatment; SARS-CoV-2; Virus-host interaction.

Publication types

  • Review

MeSH terms

  • Biomarkers* / metabolism
  • COVID-19* / genetics
  • COVID-19* / virology
  • Humans
  • RNA, Circular* / genetics
  • RNA, Circular* / metabolism
  • SARS-CoV-2* / genetics

Substances

  • RNA, Circular
  • Biomarkers