The interactions of spontaneous abortion, dietary intake of selenium, and fat mass and obesity associated (FTO) genotype: a case-control study in Iran

Narjes Nooriani; Zahra Saeedirad; Soheila Shekari; Sheyda Nami; Zahra Mahmoudi; Khadijeh Abbasi Mobarakeh; Somayyeh Bararnia Adabi; Shiva Khodarahmi; Parsa Bahmani; Saeid Doaei; Marjan Ajami; Maryam Gholamalizadeh

doi:10.3389/fnut.2024.1428648

The interactions of spontaneous abortion, dietary intake of selenium, and fat mass and obesity associated (FTO) genotype: a case-control study in Iran

Front Nutr. 2024 Dec 20:11:1428648. doi: 10.3389/fnut.2024.1428648. eCollection 2024.

Authors

Affiliations

¹ Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
² Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
⁴ Department of Clinical Biochemistry, Iran University of Medical Sciences, Tehran, Iran.
⁵ Department of Community Nutrition, Nutrition and Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
⁶ Student Research Committee, Department of Nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
⁷ School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁸ School of Nursing and Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran.
⁹ Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
¹⁰ Reproductive Health Research Center, Department of Obstetrics and Gynecology, School of Medicine, Al-Zahra Hospital, Guilan University of Medical Sciences, Rasht, Iran.
¹¹ Department of Food and Nutrition Policy and Planning, School of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
¹² Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Background: Spontaneous abortion (SA) is reported to be associated with Fat Mass And Obesity-Associated FTO genotype and dietary intake of selenium. This research assessed the potential interactions between the risk of SA, dietary selenium intake, and the FTO rs9939609 polymorphism.

Methods: This case-control study encompassed 192 women who experienced SA and 347 control participants. Dietary selenium intake was evaluated using a comprehensive food frequency questionnaire (FFQ) and Nutritionist IV software. The FTO gene was genotyped for rs9939609 polymorphism.

Result: The findings showed that there were no significant variations in the case and control groups' dietary selenium intake. A lower selenium intake was inversely associated with SA only among individuals with the TT genotype of the FTO gene (β = -0.19, p = 0.04). The results remained unchanged when age, BMI, physical activity, smoking, alcohol consumption, and calorie intake were taken into account.

Conclusion: A link may exist between selenium consumption and SA, especially in individuals with the TT genotype in the FTO gene. These findings underline the influence of genetic factors on how dietary intake impacts SA. Further investigation is required to validate these conclusions.

Keywords: FTO gene; abortion; diet; selenium; spontaneous abortion.

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. National Institute for Medical Research Development, Tehran, Iran, provided financial support for the investigation (Code 4021687).