Transcranial magnetic stimulation (TMS) is an effective intervention for improving cognitive impairment in patients with stroke. However, its effectiveness in the subdomains of cognition is conflicting and not clearly established. This systematic review assessed the efficacy of TMS in improving executive function, attention, and memory in this population. Seven databases, including PubMed, Scopus, Cochrane Library, Cumulated Index in Nursing and Allied Health Literature, NeuroBITE, Physiotherapy Evidence Database, and OTseeker, were searched for indexed literature until July 2024 to identify all randomized controlled trials (RCTs) of this effect in stroke patients. This systematic review was performed by Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and the Handbook of the Cochrane Library and evaluated the quality of evidence using the Risk of Bias 2 tools and grading of recommendations assessment, development, and evaluation (GRADE) systems. Meta-analyses were performed using standardized mean difference (SMD) (Hedge's g) as the effect measure, and subgroups were performed to explore potential outcomes. The research included 13 RCTs involving 496 patients with stroke. The results indicated that TMS could affect executive function (six RCTs with SMD = 0.55; 95% confidence interval, CI = 0.04-1.05) and memory (nine RCTs with SMD = 0.57; 95% CI = 0.25-0.89) in patients with stroke. However, the effectiveness of TMS on attention (five RCTs with SMD = 0.32; 95% CI = -0.1 to 0.75) was not clear. The quality of the results varied between very low and low according to the GRADE approach. In conclusion, TMS may affect executive function and memory, but not attention. The quality of the evidence for the outcomes varied from very low to low owing to heterogeneity and bias; therefore, the results should be considered with caution, and more rigorous evidence is needed.
Keywords: attention; cognitive impairment; executive function; memory; meta-analysis; stroke; systematic review; transcranial magnetic stimulation.
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