Efficacy of Enhanced Rehabilitation Initiated After Hospital Discharge to Improve Quality of Life in Survivors of Critical Care: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Abstract

This systematic review and meta-analysis evaluated the effects of enhanced rehabilitation initiated after hospital discharge on the quality of life (QOL) in survivors of critical care. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) procedure. MEDLINE, CENTRAL, Ichushi, Embase, PEDro, and Cumulated Index to Nursing and Allied Health Literature (CINAHL) databases and the International Clinical Trials Registry Platform and ClinicalTrials.gov (for ongoing or unpublished trials) were searched till January 2024. We identified randomized controlled trials (RCTs) with intensive care unit (ICU) survivors focusing on the effects of enhanced rehabilitation initiated after hospital discharge. Enhanced rehabilitation encompasses protocolized programs offering more intensive, frequent, or longer sessions than standard care. Primary outcomes were physical and mental components of the summary of the standardized QOL scale (SF-36) and adverse events. We calculated pooled-effect estimates for these components, expressing the mean difference (MD) and 95% confidence interval (CI). Risk of bias was evaluated using the Risk of Bias 2 tool. Certainty of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. Nine RCTs (573 patients) were included. Enhanced rehabilitation resulted in no difference in the physical component-summary score (two studies: n=79, MD=3.03, 95% CI: -1.37 to 7.43, I²=0%, low-certainty evidence) and a higher mental component-summary score (two studies: n=79, MD=7.27, 95% CI: 2.08-12.46, I²=0%, low-certainty evidence). The evidence on the effect of enhanced rehabilitation on adverse events was very uncertain (nine studies: n=558, risk difference: 0.04, 95% CI: 0.00-0.07, I²=65%, very low-certainty evidence). Seven studies reported no adverse event occurrence, one reported a serious event requiring hospitalization in the intervention group, and another reported a minor event in the intervention group with none in controls. Enhanced rehabilitation initiated after hospital discharge may improve the mental component of QOL for survivors in the critical care. Due to the smaller number of studies included, the results need further confirmation.

Keywords: critical illness; medical critical care; post-intensive care syndrome (pics); quality of life; rehabilitation.