Fe3O4/Ni nanoparticles anchored nitrogen-doped porous carbon derived from core-shell MOF for simultaneous electrochemical detection of dopamine and 5-hydroxytryptamine

Zihan Huang; Hongfeng Lu; Hui Dong; Zhiao Chen; Renwei Lu; Yangguang Zhao; Yanru Du; Yuhan Liu; Yuhan Wu; Maotian Xu; Yanfeng Bi; Yanli Zhou

doi:10.1016/j.talanta.2025.127522

Fe₃O₄/Ni nanoparticles anchored nitrogen-doped porous carbon derived from core-shell MOF for simultaneous electrochemical detection of dopamine and 5-hydroxytryptamine

Talanta. 2025 Jan 6:286:127522. doi: 10.1016/j.talanta.2025.127522. Online ahead of print.

Authors

Zihan Huang¹, Hongfeng Lu², Hui Dong³, Zhiao Chen³, Renwei Lu³, Yangguang Zhao³, Yanru Du³, Yuhan Liu³, Yuhan Wu³, Maotian Xu³, Yanfeng Bi⁴, Yanli Zhou⁵

Affiliations

¹ Henan Key Laboratory of Biomolecular Recognition and Sensing, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, 476000, PR China; School of Petrochemical Engineering, Liaoning Petrochemical University, Fushun, Liaoning, 113001, PR China.
² Lab of Biosystem and Microanalysis, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, PR China.
³ Henan Key Laboratory of Biomolecular Recognition and Sensing, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, 476000, PR China.
⁴ School of Petrochemical Engineering, Liaoning Petrochemical University, Fushun, Liaoning, 113001, PR China.
⁵ Henan Key Laboratory of Biomolecular Recognition and Sensing, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, 476000, PR China. Electronic address: zhouyanli@mails.ucas.ac.cn.

PMID: 39765080
DOI: 10.1016/j.talanta.2025.127522

Abstract

Pre-designed core-shell metal-organic frameworks (MOFs@MOFs) with customized functionalities can enhance the material properties compared to conventional single MOFs. The porous carbon composites derived from MOFs@MOFs also have excellent functionality due to the presence of multiple metal/metal oxide nanoparticles. This paper synthesized a novel MOFs@MOFs composite (MIL-101(Fe)@Ni-MOF) with a core-shell structure with MIL-101(Fe) as the core and Ni-MOF as the shell. After pyrolysis of the above composite, nitrogen-doped porous carbon (Fe₃O₄/Ni@NPC) anchored with Fe₃O₄ nanoparticles and Ni nanoparticles with synergistic catalytic effects were constructed. Fe₃O₄/Ni@NPC exhibited synergistic catalytic effects for the synchronous and ultra-sensitive detection of dopamine (DA) and 5-hydroxytryptamine (5-HT) with a detection limit of 0.165 μM for DA and 0.327 μM for 5-HT. Highly accurate and sensitive target detection was also achieved in experiments with human serum and PC12 cells, which was of great clinical importance.

Keywords: Core-shell metal-organic frameworks; Electrochemical sensors; Monoamine neurotransmitters; PC12 cells; Porous carbon materials.