Do low-risk patients really need follow-up after a pulmonary embolism?

J R Coll Physicians Edinb. 2025 Jan 8:14782715241311959. doi: 10.1177/14782715241311959. Online ahead of print.

Abstract

Background: The British Thoracic Society recommend that pulmonary embolism (PE) patients with low-risk Pulmonary Embolism Severity Index (PESI) scores are considered for outpatient (OP) management, in settings where robust pathways for follow-up and monitoring exist.

Methods: Retrospective cohort study. We reviewed the electronic records of 109 consecutive PE patients considered appropriate for OP management. Primary outcomes were the incidence of recurrent venous thromboembolism, major bleeding, mortality at 1 year and evidence of chronic thromboembolic pulmonary hypertension (CTEPH).

Results: Low-risk PESI scores (I-II) were recorded in 78 (72%) patients, with higher scores a consequence of age and comorbidity rather than haemodynamic instability. There was a low rate of adverse outcomes despite a lack of formal follow up for most patients. There was no evidence of CTEPH in 34 patients who underwent echocardiography.

Conclusion: Our analysis challenges the need for robust follow-up pathways for all patients with pulmonary embolism.

Keywords: Chronic thromboembolic pulmonary hypertension (CTEPH); PESI scores; anticoagulant associated bleeding; follow-up; low risk PE; mortality.