Objective To understand the research status of osteoimmunology by a bibliometric study and provide reference for potential research hotspots in the future. Methods The articles and reviews related to osteoimmunology were retrieved from the Web of Science Core Collection with the time interval from 2002 to 2022.VOSviewer,CiteSpace,and the Bibliometrix package in R were used to analyze the contributions and co-citation relationships of countries/regions,institutions,journals,authors,references,and keywords,and identify research hotspots. Results A total of 812 English-language articles published between 2002 and 2022 were collected,and the annual number of articles was increasing year by year.China had the most articles (n=233,28.69%),followed by the United States and Japan.Sichuan University had the highest number of articles (n=35,4.27%).Takayanagi H ranked first among both publishing authors and co-cited authors.Froniters in Immunology was the journal publishing the highest number of articles (n=45,impact factor of 7.3 in 2023) in this field.The clustering of key nodes and identification of keywords in co-cited references indicated that the research of osteoimmunology mainly focused on signal transduction mechanisms of bone immunity,bone immunity-mediated diseases,and drug treatment.In recent years,the research hotspots of osteoimmunology included macrophage polarization,bone biomaterials,bone regeneration,and therapy. Conclusion This study employed bibliometric methods to comprehensively analyze the countries,institutions,authors,keywords,and references of articles in osteoimmunology,providing guidance and reference for researchers engaged in this field.
目的 通过对骨免疫知识领域进行文献计量学分析,了解骨免疫知识领域演进动态,并为未来可能的研究热点提供参考。方法 从Web of Science Core Collection获得2002至2022年骨免疫相关的论著和综述,使用VOSviewer、CiteSpace和R软件中的Bibliometrix包,分析国家/地区、机构、期刊、作者、参考文献、关键词的贡献和共引用关系,并确定研究热点。结果 收集2002至2022年发表的812篇英文文献,论文数量每年都在增加。大多数出版物来自中国(n=233,28.69%),其次是美国和日本。四川大学发文最多(n=35,4.27%)。Takayanagi H在发文作者和共引用作者中均排名第一。Froniters in Immunology是载文量最多的期刊(n=45,2023年影响因子:7.3)。共引用参考文献关键节点的聚类和关键词的识别显示骨免疫研究的3个主要方面包括骨免疫信号转导机制、骨免疫介导相关疾病、药物治疗。目前,骨免疫知识领域的研究热点集中于巨噬细胞极化、骨生物材料、骨再生和治疗。结论 通过对骨免疫知识领域相关文献的国家、机构、作者、关键词和参考文献进行分析,为对该领域感兴趣的研究人员提供指导和参考。.
Keywords: bibliometrics; bone biomaterial; bone regeneration; macrophage polarization; osteoimmunology; therapy.