Genetically Engineered Hypoimmune Human Muscle Progenitor Cells Can Reduce Immune Rejection

Yu Chen; Peng Wang; Shilin Ma; Chenran Yue; Xupeng Liu; Yeqian Cheng; Kun Liu; Tongbiao Zhao; Ng Shyh-Chang

doi:10.1111/cpr.13802

Genetically Engineered Hypoimmune Human Muscle Progenitor Cells Can Reduce Immune Rejection

Cell Prolif. 2025 Jan 7:e13802. doi: 10.1111/cpr.13802. Online ahead of print.

Authors

Yu Chen^{1

2

3}, Peng Wang^{1

3}, Shilin Ma^{1

2

3}, Chenran Yue^{1

2

3}, Xupeng Liu^{1

2

3}, Yeqian Cheng^{1

3}, Kun Liu^{1

3}, Tongbiao Zhao^{1

2

3}, Ng Shyh-Chang^{1

2

3}

Affiliations

¹ Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
² Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
³ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.

PMID: 39777760
DOI: 10.1111/cpr.13802

Abstract

Cells face two challenges after transplantation: recognition and killing by lymphocytes, and cell apoptosis induced by the transplantation environment. Our hypoimmune cells aim to address these two challenges through editing of immunomodulatory proteins and overexpression of anti-apoptotic proteins.

Publication types

Letter

Grants and funding

2019YFA0801700/National Key Research and Development Program of China