Ferric chloride mediated dearomative spirocyclization of biaryl ynones for the synthesis of new series of densely functionalized 3,3-spiroindanone derivatives has been reported. This study is the first to describe the regioselective synthesis of a five-membered ring from biaryl ynones. The scope of the reaction is broad and the spirocyclic products were obtained in moderate to good yields (up to 87 %) and with high stereoselectivities.
Keywords: Dearomatization; Ferric chloride; Green solvent; Spirocyclization; Spiroindanone.
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