False-Positive Uptake of 123I-MIBG in the Basal Ganglion in a Pediatric Neuroblastoma Patient

Yanfeng Xu; Siqi Li; Xia Lu; Wei Wang; Jigang Yang

doi:10.1097/RLU.0000000000005661

False-Positive Uptake of 123I-MIBG in the Basal Ganglion in a Pediatric Neuroblastoma Patient

Clin Nucl Med. 2025 Jan 9. doi: 10.1097/RLU.0000000000005661. Online ahead of print.

Authors

Yanfeng Xu¹, Siqi Li, Xia Lu, Wei Wang, Jigang Yang

Affiliation

¹ From the Department of Nuclear Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

PMID: 39780370
DOI: 10.1097/RLU.0000000000005661

Abstract

A 7-year-old boy with high-risk neuroblastoma underwent 123I-MIBG SPECT/CT to evaluate the therapy response. The scan revealed abnormal 123I-MIBG uptake in the left basal ganglion, indicating the possibility of brain metastasis. Subsequent contrast-enhanced brain MRI, however, did not show any abnormal signal intensity in the left basal ganglion. Follow-up 123I-MIBG SPECT/CT scans at 3-month and 9-month also did not show abnormal MIBG uptake in the same area. The case highlights the possibility of false-positive uptake of 123I-MIBG in the basal ganglion.