Nanocavity-based single-molecule plasmon-enhanced Raman spectroscopy: Features and advancements

Peng-Yu Wang; Liao-Liao Zuo; Jie-Du Wu; Chao-Yu Li; Jian-Feng Li

doi:10.1016/j.saa.2024.125664

Nanocavity-based single-molecule plasmon-enhanced Raman spectroscopy: Features and advancements

Spectrochim Acta A Mol Biomol Spectrosc. 2024 Dec 25:330:125664. doi: 10.1016/j.saa.2024.125664. Online ahead of print.

Authors

Peng-Yu Wang¹, Liao-Liao Zuo¹, Jie-Du Wu¹, Chao-Yu Li², Jian-Feng Li³

Affiliations

¹ Interdisciplinary Materials Research Center, School of Materials Science and Engineering, Tongji University, Shanghai 201804, China.
² Interdisciplinary Materials Research Center, School of Materials Science and Engineering, Tongji University, Shanghai 201804, China. Electronic address: chaoyuli@tongji.edu.cn.
³ State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, College of Energy, Xiamen University, Xiamen 361005, China.

PMID: 39787801
DOI: 10.1016/j.saa.2024.125664

Abstract

Since 1997, driven by advancements in nanoscience, single-molecule plasmon-enhanced Raman spectroscopy (SM-PERS) has developed into a powerful technique for ultrasensitive trace analysis through fingerprint vibrational chemical information. The nanocavity between the coupled plasmonic nanostructures, offering an exceptionally high Raman signal enhancement factor (i.e., plasmonic field hotspot), is crucial for the achievement of SM-PERS. Herein, we first briefly review the development of SM-PERS, followed by an introduction of the features and methodologies of SM-PERS, as well as the applications of SM-PERS in biological analysis, high-resolution chemical imaging, and the investigations of single-molecule reactions. Finally, a perspective highlighting the advancement of new methods and applications of nano-driven SM-PERS is presented.

Keywords: Nanocavity; Plasmonic; SHINERS; SM-PERS; SM-SERS; TERS.