Acral Lentiginous Melanoma. Part II. Staging, Surgical Management, The Role of Systemic Therapy, Shortcomings and Future Directions

Daniella Jaguan; Sach Thakker; Micah Belzberg; Nina Gulati; Janeth R Campbell; Brittney K DeClerck; Vishal A Patel; Gino K In

doi:10.1016/j.jaad.2024.11.076

Acral Lentiginous Melanoma. Part II. Staging, Surgical Management, The Role of Systemic Therapy, Shortcomings and Future Directions

J Am Acad Dermatol. 2025 Jan 7:S0190-9622(25)00012-X. doi: 10.1016/j.jaad.2024.11.076. Online ahead of print.

Authors

Daniella Jaguan¹, Sach Thakker¹, Micah Belzberg², Nina Gulati³, Janeth R Campbell¹, Brittney K DeClerck⁴, Vishal A Patel⁵, Gino K In⁶

Affiliations

¹ Georgetown University School of Medicine, Washington, DC.
² Department of Dermatology, Johns Hopkins School of Medicine, Baltimore, MD; Department of Dermatology, Cleveland Clinic, Cleveland, OH.
³ Tufts University School of Medicine, Boston, MA.
⁴ Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA; Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
⁵ Department of Dermatology, George Washington University, Washington, DC.
⁶ Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA; Division of Oncology, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA. Electronic address: Gino.In@med.usc.edu.

PMID: 39788429
DOI: 10.1016/j.jaad.2024.11.076

Abstract

This comprehensive review navigates the clinical management and challenges of acral lentiginous melanoma (ALM), including staging, surgical interventions, and systemic therapies. Multimodality treatment and clinical trials are recommended for advanced cases.

Keywords: acral lentiginous melanoma; chemotherapy; cutaneous oncology; dermatologic surgery; immunotherapy; melanoma; targeted therapy.

Publication types

Review