Diterpenoid alkaloids from the roots of Aconitum bulbilliferum

Yan-Yan Luo; Jin-Bu Xu; Shuai Huang; Xian-Li Zhou

doi:10.1016/j.fitote.2025.106387

Diterpenoid alkaloids from the roots of Aconitum bulbilliferum

Fitoterapia. 2025 Jan 7:106387. doi: 10.1016/j.fitote.2025.106387. Online ahead of print.

Authors

Yan-Yan Luo¹, Jin-Bu Xu², Shuai Huang², Xian-Li Zhou³

Affiliations

¹ School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, PR China; Key laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, Sichuan, PR China.
² School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, PR China.
³ School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, PR China; Key laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, Sichuan, PR China. Electronic address: zhouxl@swjtu.edu.cn.

PMID: 39788436
DOI: 10.1016/j.fitote.2025.106387

Abstract

The phytochemistry study of Aconitum bulbilliferum Hand.-Mazz. is firstly reported. Two C₂₀-diterpenoid alkaloids, named bulbilliferines A and B (1 and 2), three C₁₉-diterpenoid alkaloids, bulbillifedines A-C (3-5), and twenty known compounds (6-25) were isolated from the roots of A. bulbilliferum. The structures of these compounds were determined by the comprehensive spectroscopic analyses (HRESIMS, IR, 1D and 2D NMR). Among them, bulbilliferine A (1) is a denudatine-type diterpenoid alkaloid bearing a 16, 17-epoxy group. At a nontoxic dose of 10 mg/kg, 14-O-anisoylchasmanine (14) hydrochloride and austroconitine B (17) hydrochloride respectively exhibited the excellent analgesic effects with 83.6 % and 83.1 % inhibitions against acetic acid-induced writhing of mice.

Keywords: Aconitum bulbilliferum; Analgesic activity; Bulbilliferine a; Denudatine-type; Diterpenoid alkaloid.