Ferroptosis and tumor immunity
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2024 Aug 28;49(8):1309-1315.
doi: 10.11817/j.issn.1672-7347.2024.240389.
[Article in
English,
Chinese]
Affiliations
- 1 Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008. 1009793925@qq.com.
- 2 Hunan Key Laboratory of Skin Cancer and Psoriasis, Changsha 410008. 1009793925@qq.com.
- 3 Hunan Engineering Research Center of Skin Health and Disease, Changsha 410008. 1009793925@qq.com.
- 4 Furong Laboratory, Changsha 410078. 1009793925@qq.com.
- 5 National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha 410008. 1009793925@qq.com.
- 6 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China. 1009793925@qq.com.
- 7 Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008.
- 8 Hunan Key Laboratory of Skin Cancer and Psoriasis, Changsha 410008.
- 9 Hunan Engineering Research Center of Skin Health and Disease, Changsha 410008.
- 10 Furong Laboratory, Changsha 410078.
- 11 National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha 410008.
- 12 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China.
- 13 Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008. pengcongxy@csu.edu.cn.
- 14 Hunan Key Laboratory of Skin Cancer and Psoriasis, Changsha 410008. pengcongxy@csu.edu.cn.
- 15 Hunan Engineering Research Center of Skin Health and Disease, Changsha 410008. pengcongxy@csu.edu.cn.
- 16 Furong Laboratory, Changsha 410078. pengcongxy@csu.edu.cn.
- 17 National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha 410008. pengcongxy@csu.edu.cn.
- 18 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China. pengcongxy@csu.edu.cn.
Ferroptosis is a unique form of cell death driven by iron-dependent lipid peroxidation, with regulatory mechanisms involving metabolic dysregulation and imbalance in redox systems. Ferroptosis is closely related to various immune cells in the tumor immune microenvironment, including both anti-tumor and pro-tumor immune cells, and it demonstrates significant potential in tumor immunotherapy. A systematic review of the regulatory mechanisms of ferroptosis and its relationship with immune cells can provide deeper insights into its application prospects in tumor immunotherapy.
铁死亡是一种依赖铁的脂质过氧化驱动的独特细胞死亡形式，其调节机制涉及代谢紊乱和氧化还原系统的失衡。铁死亡与肿瘤免疫微环境中的多种免疫细胞(包括抗肿瘤和促肿瘤免疫细胞)密切相关，并在肿瘤免疫治疗中展现出巨大潜力。系统回顾铁死亡的调节机制及其与免疫细胞的关系，有助于深入了解其在肿瘤免疫治疗中的应用前景。.
Keywords:
ferroptosis; immune cells; tumor immunotherapy.
MeSH terms
-
Animals
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Ferroptosis* / immunology
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Humans
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Immunotherapy* / methods
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Iron / metabolism
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Lipid Peroxidation*
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Neoplasms* / immunology
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Tumor Microenvironment* / immunology