Differential effects of exercise training protocols on blood pressures and lipid profiles in older adults patients with hypertension: A systematic review and meta-analysis

Keyvan Hejazi; Zahra Ataran Iraj; Ayoub Saeidi; Anthony C Hackney; Fatiha Laziri; Katsuhuko Suzuki; Ismail Laher; Zouhal Hassane

doi:10.1016/j.archger.2024.105737

Differential effects of exercise training protocols on blood pressures and lipid profiles in older adults patients with hypertension: A systematic review and meta-analysis

Arch Gerontol Geriatr. 2024 Dec 31:131:105737. doi: 10.1016/j.archger.2024.105737. Online ahead of print.

Authors

Keyvan Hejazi¹, Zahra Ataran Iraj², Ayoub Saeidi³, Anthony C Hackney⁴, Fatiha Laziri⁵, Katsuhuko Suzuki⁶, Ismail Laher⁷, Zouhal Hassane⁸

Affiliations

¹ Department of Physical Education and Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran. Electronic address: k.hejazi@hsu.ac.ir.
² Department of Physical Education and Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran.
³ Department of Physical Education and Sport Sciences, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Kurdistan, Iran.
⁴ Department of Exercise & Sport Science, Department of Nutrition, University of North Carolina, Chapel Hill, NC, United States.
⁵ Laboratoire Ecologie, Environnement et Santé Equipe Santé Humaine et Environnement Faculté des Sciences de Université Moulay Ismail, Meknès, Morocco.
⁶ Faculty of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan.
⁷ Department of Anesthesiology, Pharmacology and Therapeutics, The University of British Columbia, Vancouver, Canada.
⁸ M2S (Laboratoire Mouvement, Sport, Santé), Université Rennes, Rennes, France; Institut International des Sciences du Sport (2I2S), Irodouer 35850, France. Electronic address: hassane.zouhal@univ-rennes2.fr.

PMID: 39798217
DOI: 10.1016/j.archger.2024.105737

Abstract

Decreased physical activity and high blood pressure are both risk factors for cardiovascular diseases. Controlling blood pressure within the normal range can prevent or delay these complications. This systematic review and meta-analysis analyzed the effects of different types of exercise training on the blood pressure and lipid profiles of older adults patients with hypertension. Five electronic databases (Web of Science, Cochrane, PubMed, Google Scholar, and Scopus) were searched from their inception until March 03, 2024. English publications and randomized controlled trials involving different types of exercise training treatments for hypertensive populations were included. Data were analyzed using a random-effects model to estimate weighted mean differences (WMD) and 95 % confidence intervals. The systematic search identified 1998 articles, of which 92 studies met the inclusion criteria and were deemed eligible for inclusion. The results of the meta-analysis indicated that reduced systolic (SBP) and diastolic blood pressures (DBP) after aerobic training (p < 0.01), resistance training (p < 0.01), combined (aerobic + resistance) exercise training (p < 0.01) and isometric handgrip training (p < 0.01). Significant reductions were also observed in low-density lipoprotein (LDL) and triglyceride (TG) levels following combined (aerobic + resistance) exercise training (p < 0.05 and p < 0.001), and resistance training (p < 0.01), respectively. High-density lipoprotein (HDL) levels were increased following aerobic training (p < 0.01), and combined (aerobic + resistance) exercise training (p < 0.01), but not after resistance and Tai chi training. Isometric handgrip training leads to greater reductions in blood pressure in hypertensive patients compared to the effects of aerobic, resistance, combined aerobic and resistance exercise, and tai chi training. Additional studies are needed to determine the exercise prescription protocols to maximize the health of older adults patients with hypertension.

Keywords: Age; Blood pressure; Exercise training; Hypertension disease; Meta-analysis.

Publication types

Review