The emerging landscape of small nucleolar RNA host gene 10 in cancer mechanistic insights and clinical relevance

Jingyu Zhu; Zihao Jian; Fangteng Liu; Lulu Le

doi:10.1016/j.cellsig.2025.111590

The emerging landscape of small nucleolar RNA host gene 10 in cancer mechanistic insights and clinical relevance

Cell Signal. 2025 Jan 9:111590. doi: 10.1016/j.cellsig.2025.111590. Online ahead of print.

Authors

Jingyu Zhu¹, Zihao Jian¹, Fangteng Liu², Lulu Le³

Affiliations

¹ Second Clinical Medical School, Nanchang University, Nanchang, Jiangxi, China.
² Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330008, Jiangxi, China. Electronic address: 15807031758@163.com.
³ Department of Obstetrics and Gynecology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330008, Jiangxi, China. Electronic address: ndefy13032@ncu.edu.com.

PMID: 39798772
DOI: 10.1016/j.cellsig.2025.111590

Abstract

Small nucleolar RNA host gene 10 (SNHG10) is a newly recognized long non-coding RNA (lncRNA) with significant implications in cancer biology. Abnormal expression of SNHG10 has been observed in various solid tumors and hematological malignancies. Research conducted in vivo and in vitro has revealed that SNHG10 plays a pivotal role in numerous biological processes, including cell proliferation, apoptosis, invasion and migration, drug resistance, energy metabolism, immune evasion, as well as tumor growth and metastasis. SNHG10 regulates tumor development through several mechanisms, such as competing with microRNA (miRNA) for binding sites, modulating various signaling pathways, influencing transcriptional activity, and affecting epigenetic regulation. The diverse biological functions and intricate mechanisms of SNHG10 highlight its considerable clinical relevance, positioning it as a potential pan-cancer biomarker and therapeutic target. This review aims to summarize the role of SNHG10 in tumorigenesis and cancer progression, clarify the molecular mechanisms at play, and explore its clinical significance in cancer diagnosis and prognosis prediction, along with its therapeutic potential.

Keywords: Clinical relevance; Long non-coding RNA; Molecular mechanisms; SNHG10; Tumor biomarker.

Publication types

Review