The surge of flexible, biointegrated electronics has inspired continued research efforts in designing and developing chip-less and wireless devices as soft and mechanically compliant interfaces to the living systems. In recent years, innovations in materials, devices, and systems have been reported to address challenges surrounding this topic to empower their reliable operation for monitoring physiological signals. This perspective provides a brief overview of recent works reporting various chip-less electronics for sensing and actuation in diverse application scenarios. We summarize wireless signal/data/power transmission strategies, key considerations in materials design and selection, as well as successful demonstrations of sensors and actuators in wearable and implantable forms. The final section provides an outlook to the future direction down the road for performance improvement and optimization. These versatile, inexpensive, and low-power device concepts can serve as alternative strategies to existing digital wireless electronics, which will find broad applications as bidirectional biointerfaces in basic biomedical research and clinical practices.
© 2024 The Authors. Published by American Chemical Society.