The role and research progress of tumor-associated macrophages in cervical cancer

Dan Wang; Xue Han; Hui-Ling Liu

doi:10.62347/FFXL7288

The role and research progress of tumor-associated macrophages in cervical cancer

Am J Cancer Res. 2024 Dec 25;14(12):5999-6011. doi: 10.62347/FFXL7288. eCollection 2024.

Authors

Dan Wang¹, Xue Han², Hui-Ling Liu²

Affiliations

¹ Department of First Clinical Medical College, Gansu University of Chinese Medicine Lanzhou, Gansu, China.
² Department of Gynecology, Gansu Provincial People's Hospital Lanzhou, Gansu, China.

Abstract

Tumor-associated macrophages (TAMs) are important immune cells in the tumor micro-environment (TME) and play a key role in the occurrence and development of cervical cancer. Besides, targeting TAMs can significantly inhibit cervical cancer tumor growth, invasion, metastasis, and angiogenesis as well as affect immune regulation. This review summarizes the correlation between TAM and tumors, the mechanism of action of TAM in cervical cancer, and the potential application of TAM in the treatment of cervical cancer. Therefore, this study may provide new ideas and targets for the development of further treatment strategies for cervical cancer patients.

Keywords: Cervical cancer; immunotherapy; polarization; tumor microenvironment; tumor-associated macrophages.

Publication types

Review