Pertussis is an important public health and clinical issue in China currently. Macrolide resistance in Bordetella pertussis is a serious challenge to prevent and manage pertussis in China. Early, timely and effective antimicrobial therapy plays an important role in alleviating disease, reducing complications and severe diseases, eliminating carriers and reducing secondary transmission, and implementing post-exposure chemoprophylaxis in special scenarios is also necessary to protect individuals at high risk of severe diseases. In view of the current situation of antimicrobial resistance to Bordetella pertussis in China, combining with the practical needs of clinical treatment and prevention and control of pertussis, this article puts forward evidence-based suggestions on antibiotic treatment and post-exposure chemoprophylaxis strategies for pertussis.
百日咳是我国当前重要的公共卫生和临床问题，百日咳鲍特菌对大环内酯类耐药是我国百日咳防治面临的严峻挑战。早期、及时、有效的抗菌药物治疗对于减轻病情、减少重症、清除带菌、减少继发传播具有重要作用，在特殊场景下实施暴露后化学药物预防可以保护重症高危个体。本文针对当前我国百日咳鲍特菌耐药现况，结合百日咳临床治疗和防控的实践需求，提出百日咳的抗菌药物治疗和暴露后药物预防策略的循证建议。.