[Corticosteroid-sensitive chemical diabetes in Horton's disease]

Nouv Presse Med. 1979 Sep 10;8(34):2735-8.
[Article in French]

Abstract

We report 5 cases of temporal arteritis associated with a diabetes whose good evolution under corticotherapy suggests a common pathogenesis. Several hypotheses can be formulated to explain the origin of the glycemic abnormality and to understand the way corticotherapy is effective. A moderate posology could at first have a hyperplasic effect on the insulin-secreting cells, and later on a favorable action on the vascular lesion and on an immunological disorder. Any definitive conclusion cannot be evolved yet. Only a more systematical study of the glycoregulation's abnormalities in the temporal arteritis will enable to answer the many remaining questions.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use*
  • Aged
  • Animals
  • Diabetes Mellitus / drug therapy
  • Diabetes Mellitus / etiology*
  • Diabetes Mellitus / metabolism
  • Female
  • Giant Cell Arteritis / complications*
  • Giant Cell Arteritis / metabolism
  • Guinea Pigs
  • Humans
  • Insulin / blood

Substances

  • Adrenal Cortex Hormones
  • Insulin