Vagal bradycardia produced by microinjections of morphine-like drugs into the nucleus ambiguus in anaesthetized dogs

Eur J Pharmacol. 1979 Nov 16;59(3-4):287-91. doi: 10.1016/0014-2999(79)90292-9.

Abstract

The site in the dog medulla oblongata where fentanyl or met-enkephalinamide produced vagal bradycardia was determined using microinjections. The nucleus ambiguus was found to be a selective and highly sensitive area for the vagal bradycardia.

MeSH terms

  • Animals
  • Dogs
  • Electric Stimulation
  • Endorphins / pharmacology*
  • Enkephalins / administration & dosage
  • Enkephalins / pharmacology*
  • Female
  • Fentanyl / administration & dosage
  • Fentanyl / pharmacology*
  • Heart Rate / drug effects*
  • Hemodynamics / drug effects
  • Injections
  • Male
  • Medulla Oblongata / physiology*
  • Microinjections
  • Splanchnic Nerves / drug effects
  • Vagus Nerve / physiology*

Substances

  • Endorphins
  • Enkephalins
  • Fentanyl