Identification of cholecystokinin-secreting cells

Lancet. 1975 Nov 22;2(7943):1016-8. doi: 10.1016/s0140-6736(75)90297-4.

Abstract

Cholecystokinin (C.C.K.)-producing cells were identified in the mucosa of the upper small intestine in man and other mammals by immunocytochemical techniques and electron microscopy on semi-thin and serial thin sections. Ultrastructural studies suggested that the C.C.K.-producing cells resemble I cells of the modified Wiesbaden classification. The combination of these techniques provides a simple and reliable method of identifying C.C.K. cells in human biopsy material and will be useful in the investigation and diagnosis of gut endocrine dysfunctions.

MeSH terms

  • Animals
  • Cholecystokinin / metabolism*
  • Dogs
  • Duodenum / cytology
  • Duodenum / ultrastructure
  • Fluorescent Antibody Technique
  • Histocytochemistry / methods
  • Humans
  • Ileum / cytology
  • Ileum / ultrastructure
  • Intestinal Mucosa / cytology*
  • Intestine, Small / cytology*
  • Jejunum / cytology
  • Jejunum / ultrastructure
  • Stomach / cytology
  • Stomach / ultrastructure
  • Swine

Substances

  • Cholecystokinin