Retrograde amnesia: production of skseletal but not cardiac response gradient by electroconvulsive shock

Science. 1970 Sep 18;169(3951):1224-6. doi: 10.1126/science.169.3951.1224.

Abstract

Rats given a single electroconvulsive shock immediately after but not 60 seconds after an aversive conditioning trial exhibited behavioral retention deficits 24 hours later in a one-trial passive avoidance task. In contrast to these differential performance deficits, similar heart-rate changes, indicative of fear retention, were seen in punished animals irrespective of the time of delivery of the shock. These data suggest retention of a generalized fear to the training experience that was not revealed by the behavioral measure. The potential usefulness of concomitant behavioral and physiological response assessment in consolidation research is discussed.

MeSH terms

  • Amnesia / etiology*
  • Analysis of Variance
  • Animals
  • Avoidance Learning
  • Bradycardia / etiology
  • Electroshock*
  • Fear
  • Habituation, Psychophysiologic
  • Heart Rate
  • Humans
  • Male
  • Memory
  • Punishment
  • Rats
  • Tachycardia / etiology