Transfer of murine experimental autoimmune encephalomyelitis and cell-mediated immunity to myelin protein is effected by Lyt-1 cells

J Neuroimmunol. 1983 Feb;4(1):61-5. doi: 10.1016/0165-5728(83)90064-4.

Abstract

Cellular transfer of experimental autoimmune encephalomyelitis (EAE) was effected in mice with lymph node cells (LNC) from appropriately immunized donors. Pretreatment of LNC with anti-Lyt-1 and Lyt-2,3 antibodies indicated that the transfer of both EAE and a cell-mediated immune response in vitro to MBP was dependent on a subpopulation of T lymphocytes expressing the phenotype associated with the helper and cell-mediated delayed hypersensitivity functions, Lyt-1+, 2-.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology*
  • Encephalomyelitis / immunology*
  • Female
  • Immunity, Cellular
  • Immunization, Passive*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred Strains
  • Myelin Basic Protein / immunology
  • T-Lymphocytes / immunology*

Substances

  • Myelin Basic Protein