The possible involvement of adenylate cyclase inhibition in the field potential suppression through alpha-2 adrenergic receptors in the bed nucleus of the stria terminalis

Brain Res. 1984 Feb 13;293(1):187-90. doi: 10.1016/0006-8993(84)91469-0.

Abstract

Catecholamines, such as norepinephrine (NE), cause a field potential suppression through alpha-2 adrenergic receptors in thin sections of the bed nucleus of the stria terminalis. Phosphodiesterase inhibitors or cyclic AMP (cAMP) analogues attenuate the NE-induced suppression. These results suggest that the NE-induced suppression is mediated by adenylate cyclase inhibition and a resultant decrease of intracellular cAMP content.

MeSH terms

  • 1-Methyl-3-isobutylxanthine / administration & dosage
  • 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone / administration & dosage
  • Adenosine / administration & dosage
  • Adenosine / analogs & derivatives
  • Adenylyl Cyclase Inhibitors*
  • Animals
  • Bucladesine / administration & dosage
  • Deoxyadenosines / administration & dosage
  • Diencephalon / drug effects*
  • Drug Interactions
  • Electrophysiology
  • Guinea Pigs
  • Norepinephrine / pharmacology*
  • Receptors, Adrenergic, alpha / drug effects*
  • Thionucleosides / administration & dosage

Substances

  • Adenylyl Cyclase Inhibitors
  • Deoxyadenosines
  • Receptors, Adrenergic, alpha
  • Thionucleosides
  • 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
  • 5'-methylthioadenosine
  • Bucladesine
  • Adenosine
  • 1-Methyl-3-isobutylxanthine
  • Norepinephrine