Protection by picolinamide, a novel inhibitor of poly (ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets

Biochem Biophys Res Commun. 1980 Jul 16;95(1):474-81. doi: 10.1016/0006-291x(80)90762-7.
No abstract available

MeSH terms

  • Amides / pharmacology
  • Animals
  • Cell Nucleus / drug effects
  • Diabetes Mellitus, Experimental / chemically induced
  • Islets of Langerhans / drug effects*
  • Islets of Langerhans / metabolism
  • Male
  • NAD / metabolism*
  • NAD+ Nucleosidase / antagonists & inhibitors*
  • Niacinamide / pharmacology
  • Picolinic Acids / pharmacology*
  • Poly(ADP-ribose) Polymerase Inhibitors*
  • Poly(ADP-ribose) Polymerases / metabolism
  • Proinsulin / biosynthesis*
  • Rats
  • Streptozocin / antagonists & inhibitors*

Substances

  • Amides
  • Picolinic Acids
  • Poly(ADP-ribose) Polymerase Inhibitors
  • NAD
  • Niacinamide
  • Streptozocin
  • Proinsulin
  • Poly(ADP-ribose) Polymerases
  • NAD+ Nucleosidase
  • picolinamide