Inclusion body myositis. Clinical, biological and ultrastructural study

J Neurol Sci. 1982 Jul;55(1):15-24. doi: 10.1016/0022-510x(82)90166-6.

Abstract

A 48-year-old patient presented for the past 4 years an amyotrophy of the quadriceps and moderate involvement of the truncal and pelvic girdle muscles. The CK level was elevated (10 times the normal rate) and the EMG revealed a fibrillation pattern on relaxation, myotonic bursts on needle insertion and reduced activity during contraction. The histological study of the muscle biopsy showed nuclear cytoplasmic inclusion bodies and pseudo-myelinic membranes. The case was classified in the inclusion body myositis group. Analysis of the other published cases underlines the variety of the clinical, biological and electromyographical aspects and abnormalities.

Publication types

  • Case Reports

MeSH terms

  • Biopsy
  • Cytoskeleton / ultrastructure
  • Electromyography
  • Humans
  • Inclusion Bodies / ultrastructure*
  • Male
  • Middle Aged
  • Muscles / pathology
  • Muscular Atrophy / pathology
  • Myofibrils / ultrastructure
  • Myositis / diagnosis
  • Myositis / pathology*