The epidermal growth factor (EGF)

Cancer. 1983 May 15;51(10):1787-91. doi: 10.1002/1097-0142(19830515)51:10<1787::aid-cncr2820511004>3.0.co;2-a.

Abstract

This review summarizes briefly some of the historical aspects of the discovery, isolation, and mode of action of epidermal growth factor (EGF). Also considered are some of the key experiments which relate the biochemical mechanisms of EGF action to the mechanism involved in oncogenic transformation by the retroviruses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Epidermal Growth Factor / isolation & purification
  • Epidermal Growth Factor / metabolism*
  • Epidermal Growth Factor / pharmacology
  • ErbB Receptors
  • Humans
  • Protein Kinases / metabolism
  • Receptors, Cell Surface / metabolism

Substances

  • Receptors, Cell Surface
  • Epidermal Growth Factor
  • Protein Kinases
  • ErbB Receptors