Effect of vitamin A palmitate on mutagenesis induced by polycyclic aromatic hydrocarbons in human cells

Carcinogenesis. 1983;4(3):245-7. doi: 10.1093/carcin/4.3.245.

Abstract

The effect of vitamin A palmitate (VAP) on mutagenesis induced by polycyclic aromatic hydrocarbons (PAH) was examined in a human epithelial-like cell line (EUE). Cultures were exposed to benzo[a]pyrene (BP), 3-methylcholanthrene (MCA), 7,12-dimethylbenz[a]anthracene, with or without VAP, and mutation frequencies were determined by selection against diphtheria toxin. A strong inhibition of mutagenesis was observed particularly with MCA and BP. VAP, in the same cell line, reduced 3H-labeled PAH binding to DNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene / toxicity*
  • Benz(a)Anthracenes / toxicity*
  • Benzo(a)pyrene
  • Benzopyrenes / toxicity*
  • Cell Line
  • Cell Survival / drug effects
  • Diterpenes
  • Epithelium / drug effects
  • Humans
  • Methylcholanthrene / toxicity*
  • Mutagenicity Tests
  • Mutagens / toxicity*
  • Retinyl Esters
  • Vitamin A / analogs & derivatives*
  • Vitamin A / pharmacology

Substances

  • Benz(a)Anthracenes
  • Benzopyrenes
  • Diterpenes
  • Mutagens
  • Retinyl Esters
  • Vitamin A
  • retinol palmitate
  • Benzo(a)pyrene
  • Methylcholanthrene
  • 9,10-Dimethyl-1,2-benzanthracene