Potassium currents in Drosophila: different components affected by mutations of two genes

Science. 1983 Jun 3;220(4601):1076-8. doi: 10.1126/science.6302847.

Abstract

Electrophysiological analysis of the Drosophila behavioral mutants Eag and Sh and the double mutant Eag Sh indicates that the products of both genes take part in the control of potassium currents in the membranes of both nerve and muscle. In voltage-clamped larval muscle fibers, Sh affects the transient A current, whereas Eag reduces the delayed rectification and, to a lesser extent, the A current.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Action Potentials
  • Animals
  • Drosophila / genetics
  • Electrophysiology
  • Genes
  • Ion Channels / metabolism*
  • Larva
  • Membrane Potentials
  • Muscles / metabolism
  • Mutation*
  • Neuromuscular Junction / metabolism
  • Potassium / metabolism*

Substances

  • Ion Channels
  • Potassium