Plasma lipids and apolipoproteins A and B in human pregnancy

Rev Esp Fisiol. 1984 Jun;40(2):183-9.

Abstract

A cross sectional study was carried out in 200 normal pregnant women between 8-40th weeks of gestation, 25 women during delivery and 25 women 6 weeks after delivery. Plasma and lipoprotein lipids were measured using standard procedures. Apolipoprotein A (Apo A) and Apolipoprotein B (Apo B), were measured by electroimmunoassay. Plasma levels of Apo A were elevated in pregnant women but the elevations were not significant until 17-20 weeks of gestation. Apo A during pregnancy was significantly correlated (p less than 0.001) with high density lipoprotein cholesterol (HDL-C). The level of Apo B increased progressively during pregnancy and it was significantly correlated (p less than 0.001) with total cholesterol (TC), plasma triglycerides (TG) and phospholipids (PL). Apo A and Apo B levels returned to non pregnant values within the puerperium, whereas TC, TG and PL remained significantly elevated above controls (p less than 0.01) 6 weeks post partum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Apolipoproteins A / blood*
  • Apolipoproteins B / blood*
  • Cholesterol / blood
  • Cross-Sectional Studies
  • Female
  • Gestational Age
  • Humans
  • Lipids / blood*
  • Phospholipids / blood
  • Postpartum Period
  • Pregnancy*
  • Triglycerides / blood

Substances

  • Apolipoproteins A
  • Apolipoproteins B
  • Lipids
  • Phospholipids
  • Triglycerides
  • Cholesterol