Abstract
T lymphocytes can produce mRNAs from the first or second constant region of the T-cell antigen receptor beta-chain. A 1.3-kilobase (kb) transcript encoding the mature protein contains V, J and one of the two C region sequences, but does not always contain D sequences. A 1.0-kb mRNA, found mainly in immature T cells, does not contain V sequences and can result from transcription that initiates upstream from an unrearranged J element.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Base Sequence
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Gene Expression Regulation
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Genes
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Humans
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Macromolecular Substances
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RNA, Messenger / genetics
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Receptors, Antigen, T-Cell / genetics*
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Recombination, Genetic
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T-Lymphocytes / physiology*
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Transcription, Genetic
Substances
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Macromolecular Substances
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RNA, Messenger
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Receptors, Antigen, T-Cell
Associated data
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GENBANK/K02778
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GENBANK/K02779
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GENBANK/K02780