Sequence and expression of transcripts of the human T-cell receptor beta-chain genes

Nature. 1984 Dec;312(5994):521-4. doi: 10.1038/312521a0.

Abstract

T lymphocytes can produce mRNAs from the first or second constant region of the T-cell antigen receptor beta-chain. A 1.3-kilobase (kb) transcript encoding the mature protein contains V, J and one of the two C region sequences, but does not always contain D sequences. A 1.0-kb mRNA, found mainly in immature T cells, does not contain V sequences and can result from transcription that initiates upstream from an unrearranged J element.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Gene Expression Regulation
  • Genes
  • Humans
  • Macromolecular Substances
  • RNA, Messenger / genetics
  • Receptors, Antigen, T-Cell / genetics*
  • Recombination, Genetic
  • T-Lymphocytes / physiology*
  • Transcription, Genetic

Substances

  • Macromolecular Substances
  • RNA, Messenger
  • Receptors, Antigen, T-Cell

Associated data

  • GENBANK/K02778
  • GENBANK/K02779
  • GENBANK/K02780