We compared the incidence and morphologic appearance of eosinophilic globules in Spitz's nevi, malignant melanoma and compound nevi. Eosinophilic globules were frequently found in Spitz's nevi, specially in those with junctional or compound features. An statistical significant increase of eosinophilic globules was found in Spitz's nevi when compared with malignant melanoma. Eosinophilic globules are not an reliable criteria for a diagnosis of a bening lesion. The use of multiple histologic parameters for differential diagnosis is necessary.