Mathematical basis of point-area deconvolution method for determining in vivo input functions

J Pharm Sci. 1978 May;67(5):663-5. doi: 10.1002/jps.2600670524.

Abstract

The point-area method for deconvolution derives a "staircase" input function which, when convolved onto the characteristic function, gives an output function coincidental with the given output data points. The area--area method for deconvolution is shown to be erroneous.

MeSH terms

  • Mathematics
  • Models, Biological*
  • Pharmaceutical Preparations / metabolism*
  • Solubility

Substances

  • Pharmaceutical Preparations