Abstract
Pretazettine hydrochloride (PTZ) has been found to inhibit protein synthesis, without being inhibitory to DNA and RNA, in Rauscher leukemic blood cells in mice for at least 6 h after its administration. With comparison to Virazole and cycloheximide, the specific anti-Rauscher virus activity of PTZ has been demonstrated only in acutely-infected NIH/3T3 cells but not in chronically-infected cells. It is not certain that the inhibitory action of PTZ on reverse transcriptase is contributory to its therapeutic activity in leukemic mice.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alkaloids / therapeutic use*
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Animals
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Antineoplastic Agents / therapeutic use*
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Cell Line
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Cytotoxicity Tests, Immunologic
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DNA, Neoplasm / biosynthesis
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DNA-Directed DNA Polymerase / metabolism
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Drug Evaluation, Preclinical
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Leukemia, Experimental / drug therapy*
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Macromolecular Substances
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Mice
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Neoplasm Proteins / biosynthesis
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RNA, Neoplasm / biosynthesis
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Rauscher Virus / drug effects
Substances
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Alkaloids
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Antineoplastic Agents
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DNA, Neoplasm
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Macromolecular Substances
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Neoplasm Proteins
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RNA, Neoplasm
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DNA-Directed DNA Polymerase