[Radioimmunoassay of high specificity for vincristine]

Quad Sclavo Diagn. 1984 Mar;20(1):79-90.
[Article in Italian]

Abstract

The authors set up a simple and fairly rapid radioimmunoassay for vincristine, that shows a good sensitivity, precision and specificity. In particular, the higher specificity in comparison with other similar dosage techniques is likely due to the marked specificity of the used anti-vincristine serum, which displays a low interference even by molecules with a vincristine-like structure. Therefore, the suggested radioimmunoassay technique seems quite suitable for studying vincristine pharmacokinetics and for monitoring blood levels of this alkaloid in treated patients.

Publication types

  • English Abstract

MeSH terms

  • Evaluation Studies as Topic
  • Humans
  • Radioimmunoassay* / standards
  • Vincristine / blood*

Substances

  • Vincristine