[Immediate cardiac toxicity of rubidazone. A case reversible by isoproterenol]

Ann Med Interne (Paris). 1983;134(7):647-50.
[Article in French]

Abstract

It is reported the first observation of cardiogenic shock without delay, in a leukemic patient during a first injection of Rubidazone (22050 RP) which is recognized so far, as one of the least cardiotoxic anthracyclines. It has been concluded: --anthracyclines, beside the risk of a progressive cardiomyopathy which is related to the dose and very well known, can induce immediate cardiac injuries, which cannot be predicted yet; --the perfect myocardial protector is still to be discovered; --in this case, beta-adrenergic stimulators appeared to be able to control the cardiotoxic effect of Rubidazone; --the last fact could be considered in the decision to maintain the treatment when such an injury occurs during a chemotherapy or when it seems absolutely necessary to use such a drug.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Antibiotics, Antineoplastic / adverse effects*
  • Daunorubicin / adverse effects
  • Daunorubicin / analogs & derivatives
  • Drug Hypersensitivity / etiology*
  • Female
  • Hemodynamics / drug effects
  • Humans
  • Isoproterenol / pharmacology*
  • Leukemia, Myeloid, Acute / drug therapy
  • Middle Aged
  • Shock, Cardiogenic / chemically induced*
  • Shock, Cardiogenic / prevention & control

Substances

  • Antibiotics, Antineoplastic
  • Isoproterenol
  • zorubicin
  • Daunorubicin