Electron imaging of crotoxin complex thin crystal at 3.5 A

J Mol Biol. 1984 May 5;175(1):93-7. doi: 10.1016/0022-2836(84)90449-2.

Abstract

Crotoxin complex forms thin crystals which are suitable for electron crystallographic analysis. We have used a 100 kV electron microscope equipped with a superconducting lens to image this crystal embedded in glucose. Optical diffraction analysis of the micrographs show unambiguously a structural resolution of 3.9 A which has not been obtained with the conventional microscope at room temperature. A density map with a nominal resolution of 3.5 A has been synthesized from these images by computer processing techniques.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Computers
  • Crotalid Venoms* / analysis
  • Crotoxin*
  • Crystallography
  • Microscopy, Electron
  • Snakes

Substances

  • Crotalid Venoms
  • Crotoxin