Properties of the spike afterhyperpolarization in pyramidal tract neurons

Brain Res. 1983 Jan 17;259(1):143-6. doi: 10.1016/0006-8993(83)91077-6.

Abstract

Features of the spike afterhyperpolarization (AHP) recorded intracellularly have been analyzed in fast pyramidal tract neurons of cats. Cell input conductance increases during the AHP, possibly because of a change in potassium conductance, as suggested by an AHP equilibrium potential 10--15 mV negative to the resting membrane potential. When more spikes are evoked in succession, AHPs following the first one are strongly reduced in amplitude. The effect is virtually maximal (30--50% of the control) after a single spike and fades out by 200-400 ms after the last spike. At short interspike intervals the initial time course of the depression is hidden by summation occurring between consecutive AHPs.

MeSH terms

  • Animals
  • Cats
  • Cell Membrane Permeability
  • Electric Conductivity
  • Evoked Potentials*
  • Potassium / metabolism
  • Pyramidal Tracts / physiology*

Substances

  • Potassium