Abstract
Severe diabetes with insulitis was produced in young diabetes-prone BB/W rats by passive transfer of concanavalin A-treated spleen cells from BB/W animals with acute diabetes. Spleen cells alone or in combination with lymph node cells were active in transferring disease.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Concanavalin A / pharmacology
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Diabetes Mellitus / etiology
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Diabetes Mellitus / immunology*
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Hyperglycemia / etiology
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Hyperglycemia / immunology
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Immunity, Cellular
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Mice
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Mice, Nude
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Rats
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Spleen / cytology
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Spleen / drug effects
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Spleen / transplantation
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Transplantation, Heterologous
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Transplantation, Homologous