Abstract
Sixteen patients with advanced squamous cell carcinoma of the head and neck were treated with a 48-hour I.V. vindesine infusion. The dosage was 3 mg/m2/48 hours every 2 weeks. Toxicity consisted of leukopenia, paresthesias, and phlebitis. Major objective responses were seen in four patients (one CR, three PR), with a median duration of 4 months.
MeSH terms
-
Aged
-
Antineoplastic Agents / administration & dosage*
-
Antineoplastic Agents / therapeutic use
-
Carcinoma, Squamous Cell / drug therapy*
-
Drug Evaluation
-
Female
-
Head and Neck Neoplasms / drug therapy*
-
Humans
-
Infusions, Parenteral
-
Male
-
Middle Aged
-
Vinblastine / administration & dosage
-
Vinblastine / analogs & derivatives*
-
Vinblastine / therapeutic use
-
Vindesine
Substances
-
Antineoplastic Agents
-
Vinblastine
-
Vindesine