Toxic, DNA-damaging and mutagenic activity of epichlorohydrin on human cells cultured in vitro

Tumori. 1983 Jun 30;69(3):191-4. doi: 10.1177/030089168306900303.

Abstract

Epichlorohydrin (ECHH) highly inhibited the tritiated thymidine uptake by human lymphocytes cultured in vitro, although the corresponding cell viability was unaffected. Furthermore, it elicited unscheduled DNA synthesis, acting as a DNA-damaging agent after its metabolic activation. ECHH also showed a clear toxic and mutagenic activity toward a human epithelial-like cell line, causing a decrease in cell viability and an increase in mutants resistant to 0.05 Lf/ml of diphtheria toxin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • Cell Survival / drug effects
  • Cells, Cultured
  • Chlorohydrins / toxicity*
  • DNA / metabolism*
  • DNA Replication / drug effects
  • Diphtheria Toxin / antagonists & inhibitors
  • Drug Resistance
  • Epichlorohydrin / toxicity*
  • Epithelial Cells
  • Epithelium / drug effects
  • Humans
  • Lymphocytes / drug effects
  • Mutagens / toxicity*
  • Mutation
  • Thymidine / metabolism

Substances

  • Chlorohydrins
  • Diphtheria Toxin
  • Mutagens
  • Epichlorohydrin
  • DNA
  • Thymidine