Liposome accumulation in ischaemic intestine following experimental mesenteric occlusion

Biosci Rep. 1981 Apr;1(4):337-44. doi: 10.1007/BF01114873.

Abstract

Partial intestinal ischaemia was produced by ligation of selected primary laterals of the mesenteric artery in the rat. Both positively and negatively charged liposomes (multiply labelled with [99mTc]diethylenetriamine pentaacetic acid, [3H]methoxy-inulin, and [4-14C]-cholesterol), administered 24 h following ligation, were accumulated in ischemic (necrotic) intestine.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cholesterol
  • Intestine, Small / blood supply*
  • Inulin
  • Ischemia / metabolism*
  • Ligation
  • Liposomes / metabolism*
  • Mesenteric Arteries
  • Mesenteric Vascular Occlusion / metabolism
  • Pentetic Acid
  • Rats
  • Regional Blood Flow
  • Technetium
  • Technetium Tc 99m Pentetate

Substances

  • Liposomes
  • Technetium
  • Pentetic Acid
  • Inulin
  • Cholesterol
  • Technetium Tc 99m Pentetate